Lü Xiao-yi,Lü Guo-dong,MO Jia-qing,XU Liang,JIA Zhen-hong.A fluorescent porous silicon-based biosensor for small molecule detection[J].Optoelectronics Letters,2016,12(6):478-480 A fluorescent porous silicon-based biosensor for small molecule detection Author Name Affiliation Lü Xiao-yi  School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China  Lü Guo-dong  Xinjiang Key Laboratory of Echinococcosis, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China  MO Jia-qing  School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China  XU Liang  School of Electrical Engineering, Tianjin University of Technology, Tianjin 300384, China  JIA Zhen-hong  School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China  Abstract:       Fluorescent porous silicon was prepared as a stable biosensor chip substrate. The aminopropyltriethoxysilane (APTES) molecules are attached in the pores of the porous silicon with a crosslink method, and when the molecules are added into the chip, the fluorescence intensity is reduced according to the concentration of the APTES. Controlled experiments are also presented with the small molecule that cannot be covalently coupled, and the results show that this kind of sensor chip has better specificity. Compared with other conventional methods, this method is simple, quick and label-free. Hits: 3652 Download times: 0 View Full Text    Download reader