LIU Jianjun.Antibody-modified integrated microfluidic terahertz biosensor for detection of breast cancer biomarkers[J].Optoelectronics Letters,2024,(4):249-256 Antibody-modified integrated microfluidic terahertz biosensor for detection of breast cancer biomarkers Author Name Affiliation LIU Jianjun  School of Intelligent Engineering, Shaoguan University, Shaoguan 512005, China[*? This work has been supported by the Natural Science Foundation of Guangdong Province No.2022A1515011409, the Youth Project of National Natural Science Foundation of China Nos.52105268 and 62001200, the Science and Technology Program of Shaoguan Nos.2019sn056, 2019sn066 and 200811094530811, the Key Project of Shaoguan University Nos.SZ2017KJ08 and SZ2020KJ02, and the Natural Science Foundation of Fujian Province No.2020J01817.  Abstract:       Breast cancer is the most common malignant tumor in women, which seriously threatens the physical and mental health of women worldwide. The existing detection methods have problems, such as large sample consumption, time-consuming sample preparation, expensive equipment, and low sensitivity. In order to solve these problems, this paper proposes a method for quickly detecting breast cancer using surface-functionalized terahertz metamaterial biosensors. The use of PIK3CA-modified sensors enhances the detection sensitivity and specificity of exosomes. Based on the red shift of the sensor absorption peak caused by exosomes, breast cancer patients can be distinguished from healthy controls. This study demonstrates that exosome detection is effective for the repeatable and non-invasive diagnosis of breast cancer patients. The terahertz metamaterial biosensor designed in this paper has high specificity, repeatability, and sensitivity, and has great potential for application in the development of modern diagnostic instruments. Hits: 0 Download times: 0 View Full Text    Download reader