| Medications for common cold are used routinely in daily life, and most of these are compounded to be more effective for people suffering from common cold. The composition and quality of the coating, a common component of tablets, have been of great concern. In this paper, laser-induced breakdown spectroscopy (LIBS), with advantages of rapid, real-time, and in-situ analysis, was used for surface analysis of tablets with and without coating film for common cold. Firstly, the spectra of compound paracetamol and amantadine hydrochloride tablets (CPAHT) and compound diclofenac sodium and chlorphenamine maleate tablets (CDSCMT), without and with coating film, respectively, were analyzed. Secondly, two kinds of tablets were investigated in-situ at depth to analyze the changes of atomic and molecular spectral line intensities under different number of laser pulses and verified using LIBS imaging method. Finally, the Ca and Ti elements in CDSCMT were analyzed by calibration free LIBS (CF-LIBS) to further verify the elemental content differences at different depth in the tablets with coating film. These results indicate that the LIBS technology can be used in fast, in-situ, depth, and multi-element detection for cold medication tablets. |
