The traditional eye sensitivity function based on photopic vision is not applicable in the mesopic vision state. The mesopic vision is studied by using the photopic and scotopic vision state sensitivity functions. And the model which links the mesopic sensitivity with the photopic and scotopic states is built. Based on the model, the luminous efficacy of mesopic vision is calculated and applied to the spectrum distribution of LED light sources. The results show that the luminous efficacy of a commercial YAG phosphor converted white LED is up to 172.7 lm/W at mesopic vision, which is 67.2% higher than that of photopic vision state. We also conclude that the optimal spectral power distribution of the LED will greatly increase the mesopic luminous efficacy.