Visible light communication (VLC), endowed with its distinctive merits, exhibits significant potential for deploy-ment in applications such as intelligent residential environments and the industrial Internet of Things (IIoT). To tackle the challenges posed by the mobility of multiple users across cells, encompassing difficulties in phase syn-chronization and diminished transmission efficiency, this paper introduces a networking protocol predicated on adaptive frame structuring by a primary user and multi-Comma code synchronization. The protocol facilitates dis-tributed user synchronization independent of a global clock by employing multi-Comma code phase alignment, thereby addressing issues of uplink phase misalignment and primary user mismatch. Additionally, to alleviate problems such as the ping-pong effect encountered during multi-cell handover, an arbitration-based frame-switching mechanism is implemented. This mechanism utilizes dynamic decision thresholds to suppress boundary interference and incorporates priority-polling hybrid arbitration, which decreases handover latency to 12 milliseconds. Exper-imental evaluations conducted on a field-programmable gate array (FPGA)-based VLC system substantiate that the proposed scheme accomplishes stable networking of three users at a data rate of 1 Mbps within a coverage diameter of 5 meters, achieving a packet loss rate of 0% across four access point handovers. These results affirm the feasi-bility and robustness of the proposed approach.